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Table 1 Number of significant interactions detected in Stage 2 of the simultaneous and the conditional designs by logistic regression modeling [Eq. (3) and (4)].

From: Two-stage strategies to detect gene × gene interactions in case-control data

  Full model without covariates [Eq. (3)] Additive effects with covariates [Eq. (4)]
  i aa i ad i da i dd i aa
Simultaneous design p < 0.05 863,970 tests 399,171 tests
<1,000 kb 46 0 0 1 206
>1,000 kb 11 0 0 0 70
Simultaneous design p < 0.10 925,480 tests 869,221 tests
<1,000 kb 46 0 0 1 209
>1,000 kb 11 0 0 0 93
Conditional design 4,069,398 tests 3,656,028 tests
<1,000 kb 49 0 0 0 353
>1,000 kb 75 0 0 4 617