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Table 1 Expecteda (Exp.) and Observed (Obs.) family configurations, genotypes and stratified IBD distributions for PTPN22 rs2476601

From: Modeling of PTPN22 and HLA-DRB1 susceptibility to rheumatoid arthritis

     IBD distribution (%)
   Genotype distribution (%) IBD = 2 IBD = 1 IBD = 0
Family configurationb Genotype Exp. Obs. Exp. Obs. Exp. Obs. Exp. Obs.
C2 TT 1 2 42 25 47 75 11 0
nf = 447 Obs. TC 24 24 34 25 50 48 16 27
nf = 449 Exp. CC 75 74 26 22 50 55 24 23
C4 TT 3 2 - 50 - 50 - 0
nf = 147 Obs. TC 31 32 33 22 50 61 17 17
nf = 144 Exp. CC 66 66 26 36 50 41 24 23
C6 TT 5 0 - - - - - -
nf = 10 Obs. TC 35 30 - 50 - 50 - 0
nf = 11 Exp. CC 60 70 - 0 - 50 - 50
  1. aExpected distributions are given under the co-dominant model.
  2. bFamily configurations: C2, sibs are affected; parents are unaffected; C4, sibs are affected; one parent is affected; C6, sibs and parents are affected;
  3. nf, number of families.
  4. -, not computed. Genotype distributions for which the sample size is ten or less, and IBD distributions for which the sample size is five or less are not include in the model.