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Table 2 Penetrance and coupling associated with PTPN22 rs2476601

From: Modeling of PTPN22 and HLA-DRB1 susceptibility to rheumatoid arthritis

Genotype Co-dominant Dominant model Recessive model
Penetrancea    
   TT 1 1 1
   TC 0.54 [0.42–0.75] 1 0.17 [0.13–0.22]
   CC 0.20 [0.12–0.30] 0.20 [0.14–0.28] 0.17 [0.13–0.22]
Coupling    
   T 0.99 [0.54–1] 0.27 [0.15–0.43] 0.99 [0.96–1]
   C 0.07 [0–0.13] 0.01 [0–0.02] 0.22 [0.19–0.28]
-2*log likelihood -2066.63 -2073.72 -2093.58
p-value 0.20 0.02 1.5 × 10-5
  1. aThe reference genotype is TT