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Table 3 Penetrance and coupling associated with PTPN22 stratified by rheumatoid factor (RF) status

From: Modeling of PTPN22 and HLA-DRB1 susceptibility to rheumatoid arthritis

  Patient status  
Genotype RF+ RF- Total sample
Penetrancea    
   TT 1 1 1
   TC 0.55 0.34 0.52
   CC 0.19 0.20 0.19
Coupling    
   T 0.96 0.99 0.97
   C 0.07 0.13 0.07
-2*log likelihood 1677.152 367.36 2047.328
p-value 0.33 0.23 0.20
  1. aThe global penetrance is set to 0.37 in all models. The reference genotype is TT.