| | |
Two children in each familyb
|
One child in each familyb
|
---|
Sample size
|
Minor allele frequency
|
α
a
|
PDT
|
T
pc
|
T
cc
|
T
cb
|
PDT
|
T
pc
|
T
cc
|
T
cb
|
---|
100 families, 120 controls
|
0.1
|
0.05
|
0.014
|
0.032
|
0.043
|
0.042
|
0.031
|
0.033
|
0.044
|
0.043
|
| |
0.1
| |
0.023
|
0.028
|
0.032
| |
0.029
|
0.041
|
0.029
|
| |
0.2
| |
0.025
|
0.027
|
0.027
| |
0.031
|
0.031
|
0.026
|
|
0.3
|
0.05
|
0.024
|
0.042
|
0.049
|
0.047
|
0.036
|
0.05
|
0.045
|
0.053
|
| |
0.1
| |
0.04
|
0.043
|
0.035
| |
0.051
|
0.047
|
0.046
|
| |
0.2
| |
0.046
|
0.038
|
0.037
| |
0.054
|
0.047
|
0.053
|
500 families, 600 controls
|
0.1
|
0.05
|
0.048
|
0.051
|
0.051
|
0.059
|
0.053
|
0.052
|
0.054
|
0.051
|
| |
0.1
| |
0.04
|
0.052
|
0.042
| |
0.052
|
0.041
|
0.045
|
| |
0.2
| |
0.042
|
0.046
|
0.044
| |
0.04
|
0.047
|
0.05
|
|
0.3
|
0.05
|
0.059
|
0.053
|
0.047
|
0.045
|
0.042
|
0.046
|
0.04
|
0.042
|
| |
0.1
| |
0.054
|
0.042
|
0.046
| |
0.048
|
0.034
|
0.044
|
| |
0.2
| |
0.053
|
0.034
|
0.048
| |
0.047
|
0.043
|
0.041
|
- aα, the cut-off p-value of the test in the first stage
- bPDT, pedigree disequilibrium test; T
pc
, test comparing all parents to controls; T
cc
, test comparing affected and unaffected parents; T
cb
, combined T
pc
and T
cc