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Table 2 Power for detecting SNP 3455 based on the dense SNP data of chromosome 6 by using 150 families and 200 unrelated controls

From: Genome-wide association tests by two-stage approaches with unified analysis of families and unrelated individuals

  Two children in each familyb One child in each familyb
α a PDT T pc T cc T cb PDT T pc T cc T cb
0.01   0.93 0.15 0.96   0.66 0.13 0.87
0.05   0.95 0.39 0.96   0.65 0.29 0.8
0.1 0.83 0.96 0.54 0.96 0.53 0.64 0.4 0.75
0.3   0.91 0.77 0.91   0.58 0.53 0.61
0.5   0.88 0.81 0.88   0.56 0.54 0.56
  1. aα, the cut-off p-value of the test in the first stage
  2. bPDT, pedigree disequilibrium test; T pc , test comparing all parents to controls; T cc , test comparing affected and unaffected parents; T cb , combined T pc and T cc