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Table 3 Power for detecting marker 3917 based on the dense SNP data of chromosome 6 by merging two replicate data sets to increase sample size

From: Genome-wide association tests by two-stage approaches with unified analysis of families and unrelated individuals

  Two children in each familyb One child in each familyb
α a PDT T pc T cc T cb PDT T pc T cc T cb
0.01   0.36 0.22 0.44   0.24 0.18 0.32
0.05   0.56 0.32 0.68   0.4 0.28 0.52
0.1 0.56 0.54 0.42 0.68 0.3 0.42 0.36 0.54
0.3   0.58 0.54 0.64   0.32 0.28 0.32
0.5   0.62 0.56 0.64   0.34 0.28 0.34
  1. aα, the cut-off p-value of the test in the first stage
  2. bPDT, pedigree disequilibrium test; T pc , test comparing all parents to controls; T cc , test comparing affected and unaffected parents; T cb , combined T pc and T cc