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Table 3 Power for detecting marker 3917 based on the dense SNP data of chromosome 6 by merging two replicate data sets to increase sample size

From: Genome-wide association tests by two-stage approaches with unified analysis of families and unrelated individuals

 

Two children in each familyb

One child in each familyb

α a

PDT

T pc

T cc

T cb

PDT

T pc

T cc

T cb

0.01

 

0.36

0.22

0.44

 

0.24

0.18

0.32

0.05

 

0.56

0.32

0.68

 

0.4

0.28

0.52

0.1

0.56

0.54

0.42

0.68

0.3

0.42

0.36

0.54

0.3

 

0.58

0.54

0.64

 

0.32

0.28

0.32

0.5

 

0.62

0.56

0.64

 

0.34

0.28

0.34

  1. aα, the cut-off p-value of the test in the first stage
  2. bPDT, pedigree disequilibrium test; T pc , test comparing all parents to controls; T cc , test comparing affected and unaffected parents; T cb , combined T pc and T cc