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Table 2 Results of using different distance criterion to define cis regulators

From: The multiplicity problem in linkage analysis of gene expression data – the power of differentiating cis- and trans-acting regulators

  3 Mb 10 Mb 20 Mb
Parameter cis (<) trans (≥) cis (<) trans (≥) cis (<) trans (≥)
No. tests 9,699 3,845,729 29,827 3,825,601 52,853 3,802,575
π ^ 0 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacuWFapaCgaqcamaaBaaaleaacqaIWaamaeqaaaaa@2F9A@ (%) 87.68 95.05 89.32 95.08 89.62 95.11
Framework I, α = 0.0001
   No. rejections 69 7,974 204 7,839 302 7,741
    F D ^ R MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGgbGrcuWGebargaqcaiabdkfasbaa@300F@ (%) 1.23 4.58 1.31 4.64 1.57 4.67
   E [No. false positives] 1 365 3 363 5 361
Framework II, γ = 0.05
   No. rejections 200 8,398 519 8,113 761 7,927
   E [No. true positives] 190 7,978 493 7,707 723 7,531
Framework III, R = 2,000
   Rejection without stratification 29 1971 90 1,910 127 1,873
   Rejection with stratification 67 1933 184 1,816 222 1,778
   Overall F D ^ R MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGgbGrcuWGebargaqcaiabdkfasbaa@300F@ (%) 2.03 1.99 1.99