False discovery rate threshold (analysis of full pedigrees). Shown are the numbers of expected false-positive findings and of observed positive findings, for each threshold of Z estimated using our corrected method (full pedigree analysis). The threshold for FDR = 10% is Z = 6.4. At this threshold we detected 22 significant linkages and expect that 2.2 are false positives. See text and Table 1 for comparison with uncorrected results.