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Table 2 The locations of the SNP markers that are significantly associated with RA after Bonferroni correction at the significance level α = 0.05

From: Genome-wide association studies using an adaptive two-stage analysis for a case-control design

      ATSb
Location (kb) HWDTTa CATTa WFTa CFTa Stage 1c Stage 2d
32447.149 NSe 2.65 × 10-15 NS 4.96 × 10-14 0.53 < 0.77 2.7 × 10-15 < 5.8 × 10-5
32499.465 NS <1.0 × 10-17 NS <1.10 × 10-16 0.65 < 0.83 1.0 × 10-17 < 6.3 × 10-15
32521.277 NS <1.0 × 10-17 NS <1.10 × 10-16 NS NS
32772.203 NS 5.36 × 10-15 NS 3.44 × 10-9 0.27 < 0.65 5.4 × 10-15 < 5.7 × 10-5
37363.880 NS NS NS 1.19 × 10-6 0.0003 < 0.02 0.0003 < 0.0011
  1. aThe p-values should be compared with 0.05/674 = 7.42 × 10-5.
  2. bThe p-value should be compared with the optimal level in the two stages.
  3. cThe level in the first stage with conditional power at least 80% (α1)
  4. dThe adjusted level for the second stage (α2 = α'/(674α1))
  5. eNS: no significance