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Table 2 The locations of the SNP markers that are significantly associated with RA after Bonferroni correction at the significance level α = 0.05

From: Genome-wide association studies using an adaptive two-stage analysis for a case-control design

     

ATSb

Location (kb)

HWDTTa

CATTa

WFTa

CFTa

Stage 1c

Stage 2d

32447.149

NSe

2.65 × 10-15

NS

4.96 × 10-14

0.53 < 0.77

2.7 × 10-15 < 5.8 × 10-5

32499.465

NS

<1.0 × 10-17

NS

<1.10 × 10-16

0.65 < 0.83

1.0 × 10-17 < 6.3 × 10-15

32521.277

NS

<1.0 × 10-17

NS

<1.10 × 10-16

NS

NS

32772.203

NS

5.36 × 10-15

NS

3.44 × 10-9

0.27 < 0.65

5.4 × 10-15 < 5.7 × 10-5

37363.880

NS

NS

NS

1.19 × 10-6

0.0003 < 0.02

0.0003 < 0.0011

  1. aThe p-values should be compared with 0.05/674 = 7.42 × 10-5.
  2. bThe p-value should be compared with the optimal level in the two stages.
  3. cThe level in the first stage with conditional power at least 80% (α1)
  4. dThe adjusted level for the second stage (α2 = α'/(674α1))
  5. eNS: no significance