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Table 3 Selected expression phenotypesa with significant evidence for linkage (LOD score ≥ 3.4) from genome scans identified in all data sets normalized by three different methods

From: Impact of normalization and filtering on linkage analysis of gene expression data

   LOD score  
Gene symbol Chromosomal location RMA GCRMA PLIER cis/trans
MCP 1q32 4.19 4.12 5.29 trans
YT521 4q13.2 3.79 4.51 4.38 trans
RNF11 1pter-p22.1 4.21 3.45 4.57 trans
RASSF3 12q14.2 4.99 4.60 5.17 trans
RAB6C 2q31 6.32 6.12 4.46 trans
FAM8A1 6p22-p23 4.62 4.75 5.20 trans
ZNF217 20q13.2 4.36 4.75 4.76 trans
CREB3 9pter-p22.1 3.60 4.41 3.48 trans
PRPSAP1 17q24-q25 4.97 3.54 4.28 trans
SPAG9 17q21.33 5.09 3.90 4.19 trans
SRPK2 7q22-q31.1 3.52 5.13 3.89 trans
LOC81558 17q21.33 3.96 5.44 4.36 trans
IRF2 4q34.1-q35.1 4.28 3.48 3.61 trans
BCL2 18q21.33|18q21.3 4.41 5.86 4.78 trans
PTPN22 1p13.3-p13.1 3.76 4.25 4.61 trans
SDCBP 8q12 5.76 4.76 5.08 trans
OSBP 11q12-q13 4.21 4.46 3.71 trans
PTPN1 20q13.1-q13.2 5.22 5.12 3.77 trans
RGS12 4p16.3 5.90 4.68 4.17 trans
  1. aSome regions of these genes also exhibit copy number variation in healthy individuals (see details in the text).