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Table 1 Familial correlation coefficients and maximum LOD score of non-parametric linkage analysis after RMA normalization

From: Normalization of microarray expression data using within-pedigree pool and its effect on linkage analysis

   Familial correlation coefficienta   
   Parent-offspring Sibling Grandparent-grandchild Maximum LODb
Gene Target gene loci All arrays pool Within pedigree pool All arrays pool Within-pedigree pool All arrays pool Within-pedigree pool All arrays pool Within-pedigree pool
CHI3L2 1p12 0.308 0.2689 0.1477 0.1146 0.1274 0.082 4.08 4.25
GSTM2 1p13 0.2887 0.3217 0.3284 0.3941 0.2277 0.3412 3.15 3.58
VAMP8 2p11 0.0939 0.4196 0.4304 0.7284 0.0475 0.4261 2.7 2.18
ICAP_1A 2p25 -0.2898 c 0.1242 0.4277 0.7435 -0.1441 0.5436 1.23 1.97
CTBP1 4p16 0.3012 0.3772 0.5581 0.639 0.2002 0.3534 0.81 0.58
PPAT 4q12 0.2055 0.2545 0.4469 0.4539 0.0778 0.1774 2.24 1.77
LOC64167 5q15 0.2927 0.3464 0.2254 0.2843 0.0483 0.1295 4.61 4.12
PSPHL 7p11 0.3932 0.5599 0.4086 0.5207 0.223 0.4089 2.51 2.54
ZP3 7q11 0.4084 0.6565 0.43 0.7211 0.2311 0.5527 4.61 3.93
IRF5 7q32 0.3462 0.384 0.2874 0.314 0.0825 0.1731 3.06 2.42
HSD17B12 11p11 0.2375 0.7565 0.3892 0.8512 0.1205 0.7026 2.06 1.96
TM7SF3 12p11 0.0618 0.5035 0.1892 0.6145 -0.1298 0.3133 1.67 1.41
RPS26 12q13 0.5907 0.6533 0.7628 0.8023 0.3606 0.453 1.58 1.57
CTSH 15q25 0.421 0.5694 0.5442 0.6546 0.322 0.5205 2.29 1.6
IL16 15q26 0.0235 0.1814 0.4244 0.5689 0.047 0.2333 2.18 1.97
CPNE1 20q11 -0.0113 0.3377 0.3958 0.73 0.0512 0.3515 1.52 0.68
CSTB 21q22 0.1592 0.3987 0.2717 0.5898 -0.0075 0.2784 2.31 1.69
DDX17 22q13 0.1687 0.2588 0.1911 0.5493 0.1911 0.2523 2.02 2.74
  1. aCorrelation coefficients of 18 gene expression values by familial pairs using FCOR, S.A.G.E.v5.1.0.
  2. bMaximum allele-sharing LOD score of nonparametric linkage analysis after RMA normalization.
  3. cBold text indicates negative familial correlation coefficient.