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Table 1 Significant patterns identified with the pattern-based method

From: Pattern-based mining strategy to detect multi-locus association and gene × environment interaction

Markers in pattern No. of cases (F/M ratio)a No. of controls (F/M ratio) Odds ratio (confidence interval) Unadjusted p-valueb Adjusted p-valuec
SNP0177 (allele 1); SNP1131 (allele 1) 260 (3.9) 178 (3.3) 2.06 (1.58–2.68) 5.04 × 10-8 0.00185
SNP0177 (allele 1); SNP0610 (genotype 2/2) 259 (3.7) 180 (3.5) 2.0 (1.54–2.61) 1.57 × 10-7 0.00601
SNP0177 (allele 1); SNP1130 (allele 2) 234 (4.3) 154 (3.6) 2.06 (1.58–2.69) 8.03 × 10-8 0.00663
SNP0177 (allele 1); SNP0615 (genotype 1/1) 259 (3.7) 182 (3.4) 1.97 (1.51–2.55) 3.08 × 10-7 0.01178
SNP0177 (allele 1); SNP0603 (genotype 1/1) 229 (3.7) 151 (4.2) 2.02 (1.55–2.65) 1.49 × 10-7 0.01396
SNP0177 (allele 1); SNP0604 (genotype 2/2); SNP0605 (genotype 2/2) 258 (3.8) 182 (3.4) 1.95 (1.5–2.54) 4.42 × 10-7 0.01763
SNP0177 (allele 1); SNP0609 (genotype 1/1) 234 (3.6) 158 (3.7) 1.98 (1.52–2.58) 3.41 × 10-7 0.02822
SNP0177 (allele 1); SNP0606 (genotype 2/2) 255 (3.9) 181 (3.4) 1.92 (1.48–2.49) 8.68 × 10-7 0.03879
SNP0177 (allele 1); SNP0672 (allele 2) 273 (3.5) 202 (3.5) 1.86 (1.43–2.42) 2.33 × 10-6 0.04072
SNP0177 (allele 1); SNP0608 (genotype 1/1) 233 (3.6) 158 (3.7) 1.96 (1.5–2.56) 4.91 × 10-7 0.04161
  1. Significant patterns were ordered according to their adjusted p-values. Each pattern contains markers with either individual allele or genotype.
  2. aThe "No. of cases" column contains the number of individuals with RA who carried the specified alleles/genotypes at the specified markers in a pattern. The number in parenthesis indicates the female/male ratio. Similar arrangement was made for "No. in controls".
  3. bp-Value before the Bonferroni correction.
  4. cp-Value obtained after the Bonferroni correction.