Figure 1
TDT tests for mother-daughter transmissions, restricted to mothers with DR genotype 1/1. a, TDT for three subsets separately. Dotted vertical line indicates the location of DR locus. b, TDT scores using sub-sample A (square) versus imputed scores (line). c, TDT scores assuming all markers are genotyped in each individual (TDTall), open square) versus TDTcomb. Dotted line indicates 0.01 critical value for TDTall, and solid line represents the corresponding critical value for TDTcomb. d, Comparison of TDTall and TDTcomb after a quantile transformation.