Impact of marker density on the accuracy of association mapping

BMC Proceedings

Table 1 Association mapping of disease Loci C and D on chromosome 6

Region^a	No. SNPs	S (kb)	Λ_A - Λ_D	χ²₃	P	P _c
26	128	24882	68	14	0.002471	0.311346
27	239	26121	793	40	<10^-7	0.000001
28	348	31299	5176	128	<10^-12	<0.000001
29	176	32540	33058	322	<10^-12	<0.000001
30	153	33962	295	25	0.000017	0.002129
31	134	35638	103	15	0.001929	0.243096
32	127	37776	141	27	0.000007	0.000926
33	147	39432	50	13	0.005554	0.699754

^aA segment of consecutive regions of 10 LDUs showing nominal significant association with RA (p < 0.05). See Methods for the meaning of other symbols. Loci C and D were in regions 29 and 32 at locations of 32485 and 37234 kb, respectively.
^bP_c is Bonferroni corrected p-value for multiple tests of 126 regions (p × 126).

ISSN: 1753-6561