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Table 1 Joint genotype probability for a sib pair (genotypes are unordered)
From:
Genome-wide linkage and association analysis of rheumatoid arthritis in a Canadian population
Pr(
g
1
,
g
2
)
(
g
1
,
g
2
)
Assume HWE
Allow departure from HWE
(0, 0)
q
4
+
p
q
3
+
1
4
p
2
q
2
MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGXbqCdaahaaWcbeqaaiabisda0aaakiabgUcaRiabdchaWjabdghaXnaaCaaaleqabaGaeG4mamdaaOGaey4kaSYaaSaaaeaacqaIXaqmaeaacqaI0aanaaGaemiCaa3aaWbaaSqabeaacqaIYaGmaaGccqWGXbqCdaahaaWcbeqaaiabikdaYaaaaaa@3C19@
P
0
2
+
1
2
P
0
P
1
+
1
16
P
1
2
MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGqbaudaqhaaWcbaGaeGimaadabaGaeGOmaidaaOGaey4kaSYaaSaaaeaacqaIXaqmaeaacqaIYaGmaaGaemiuaa1aaSbaaSqaaiabicdaWaqabaGccqWGqbaudaWgaaWcbaGaeGymaedabeaakiabgUcaRmaalaaabaGaeGymaedabaGaeGymaeJaeGOnaydaaiabdcfaqnaaDaaaleaacqaIXaqmaeaacqaIYaGmaaaaaa@3E60@
(0, 1)
pq
2
(1 +
q
)
P
0
P
1
+
1
4
P
1
2
MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqWGqbaudaWgaaWcbaGaeGimaadabeaakiabdcfaqnaaBaaaleaacqaIXaqmaeqaaOGaey4kaSYaaSaaaeaacqaIXaqmaeaacqaI0aanaaGaemiuaa1aa0baaSqaaiabigdaXaqaaiabikdaYaaaaaa@3758@
(0, 2)
1
2
p
2
q
2
MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabigdaXaqaaiabikdaYaaacqWGWbaCdaahaaWcbeqaaiabikdaYaaakiabdghaXnaaCaaaleqabaGaeGOmaidaaaaa@33BA@
1
8
P
1
2
MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabigdaXaqaaiabiIda4aaacqWGqbaudaqhaaWcbaGaeGymaedabaGaeGOmaidaaaaa@31E2@
(1, 1)
pq
(1 +
pq
)
1
2
P
0
P
1
+
1
4
P
1
2
+
1
2
P
1
P
2
+
2
P
0
P
2
MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabigdaXaqaaiabikdaYaaacqWGqbaudaWgaaWcbaGaeGimaadabeaakiabdcfaqnaaBaaaleaacqaIXaqmaeqaaOGaey4kaSYaaSaaaeaacqaIXaqmaeaacqaI0aanaaGaemiuaa1aa0baaSqaaiabigdaXaqaaiabikdaYaaakiabgUcaRmaalaaabaGaeGymaedabaGaeGOmaidaaiabdcfaqnaaBaaaleaacqaIXaqmaeqaaOGaemiuaa1aaSbaaSqaaiabikdaYaqabaGccqGHRaWkcqaIYaGmcqWGqbaudaWgaaWcbaGaeGimaadabeaakiabdcfaqnaaBaaaleaacqaIYaGmaeqaaaaa@4730@
(1, 2)
p
2
q
(1 +
p
)
1
4
P
1
2
+
P
1
P
2
MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabigdaXaqaaiabisda0aaacqWGqbaudaqhaaWcbaGaeGymaedabaGaeGOmaidaaOGaey4kaSIaemiuaa1aaSbaaSqaaiabigdaXaqabaGccqWGqbaudaWgaaWcbaGaeGOmaidabeaaaaa@375C@
(2, 2)
1
4
p
2
q
2
+
p
3
q
+
p
4
MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabigdaXaqaaiabisda0aaacqWGWbaCdaahaaWcbeqaaiabikdaYaaakiabdghaXnaaCaaaleqabaGaeGOmaidaaOGaey4kaSIaemiCaa3aaWbaaSqabeaacqaIZaWmaaGccqWGXbqCcqGHRaWkcqWGWbaCdaahaaWcbeqaaiabisda0aaaaaa@3C17@
1
16
P
1
2
+
1
2
P
1
P
2
+
P
2
2
MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaadaWcaaqaaiabigdaXaqaaiabigdaXiabiAda2aaacqWGqbaudaqhaaWcbaGaeGymaedabaGaeGOmaidaaOGaey4kaSYaaSaaaeaacqaIXaqmaeaacqaIYaGmaaGaemiuaa1aaSbaaSqaaiabigdaXaqabaGccqWGqbaudaWgaaWcbaGaeGOmaidabeaakiabgUcaRiabdcfaqnaaDaaaleaacqaIYaGmaeaacqaIYaGmaaaaaa@3E68@
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