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Table 2 Power of association analyses at Locus Da

From: Density-based clustering in haplotype analysis for association mapping

 

Power, no covariates

Power, adjustedb

 
 

α = 0.05

α = 0.01

α = 0.05

α = 0.01

Mean d.f.c

6 Markers d

     

   Haplotypes

0.240

0.088

0.059

0.009

9.04

   Clusters, ε = 0.4e

0.272

0.104

--

--

4.48

   Clusters, ε = 0.5

0.271

0.098

0.079

0.022

4.43

8 Markers f

     

   Haplotypes

0.448

0.206

0.112

0.025

14.37

   Clusters, ε = 0.7e

0.470

0.239

--

--

10.26

   Clusters, ε = 0.5

0.448

0.236

0.135

0.019

10.26

  1. aPower was measured over 800 data sets of 500 each cases and controls.
  2. bSex and number of DRB1*04 alleles were included as covariates.
  3. cSee Table 1. Values shown are from analyses without covariates; mean d.f. from adjusted analyses were nearly identical.
  4. dSNPs 3914–3919.
  5. eValue of ε maximizing power for score test without covariates.
  6. fSNPs 3913–3920.
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BMC Proceedings

ISSN: 1753-6561

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