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Table 2 Power of association analyses at Locus Da

From: Density-based clustering in haplotype analysis for association mapping

  Power, no covariates Power, adjustedb  
  α = 0.05 α = 0.01 α = 0.05 α = 0.01 Mean d.f.c
6 Markers d      
   Haplotypes 0.240 0.088 0.059 0.009 9.04
   Clusters, ε = 0.4e 0.272 0.104 -- -- 4.48
   Clusters, ε = 0.5 0.271 0.098 0.079 0.022 4.43
8 Markers f      
   Haplotypes 0.448 0.206 0.112 0.025 14.37
   Clusters, ε = 0.7e 0.470 0.239 -- -- 10.26
   Clusters, ε = 0.5 0.448 0.236 0.135 0.019 10.26
  1. aPower was measured over 800 data sets of 500 each cases and controls.
  2. bSex and number of DRB1*04 alleles were included as covariates.
  3. cSee Table 1. Values shown are from analyses without covariates; mean d.f. from adjusted analyses were nearly identical.
  4. dSNPs 3914–3919.
  5. eValue of ε maximizing power for score test without covariates.
  6. fSNPs 3913–3920.