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Table 2 Two-stage analysis: selected SNPs and their corresponding p-values in the second stage

From: Joint analysis of case-parents trio and unrelated case-control designs in large scale association studies

Chromosome

SNP

Distance (Mb)

Z TDT then Z CC

Z CC then Z TDT

Z TDT or Z CC then Zjoint

6

SNP6_128

7.13

1.02 × 10-8

 

1.61 × 10-7

 

SNP6_129

7.10

4.01 × 10-13

 

1.45 × 10-8

 

SNP6_130

7.10

1.48 × 10-13

 

1.28 × 10-9

 

SNP6_134

6.41

5.76 × 10-10

 

1.33 × 10-6

 

SNP6_138 b

3.73

2.89 × 10 -15

2.85 × 10 -7

1.07 × 10 -13

 

SNP6_139

3.72

2.44 × 10 -15

3.75 × 10 -7

1.22 × 10 -13

 

SNP6_145

2.92

1.03 × 10 -9

5.20 × 10 -6

1.24 × 10 -9

 

SNP6_147

2.22

1.37 × 10 -8

 

3.05 × 10 -7

 

SNP6_150

1.39

5.99 × 10 -7

 

6.25 × 10 -7

 

SNP6_152 c

0.04

2.38 × 10 -221

1.55 × 10 -94

4.31 × 10 -193

 

SNP6_153

0.01

0*a

7.33 × 10 -206

0*a

 

SNP6_154

0.04

0*

1.23 × 10 -182

0*

 

SNP6_155

0.29

4.49 × 10 -87

1.91 × 10 -49

7.36 × 10 -86

 

SNP6_160

0.65

8.62 × 19 -10

8.20 × 10 -9

1.16 × 10 -11

 

SNP6_162

0.13

9.15 × 10 -24

1.78 × 10 -15

9.36 × 10 -26

11

SNP11_387

0.19

  

3.00 × 10 -6

 

SNP11_389

0.03

2.78 × 10 -28

3.33 × 10 -15

2.41 × 10 -27

18

SNP18_269

0.02

2.25 × 10 -8

 

1.56 × 10 -8

  1. a0*, p-value < 10-300. Test statistics are based on an additive genetic model.
  2. bItalic, SNPs within 5 Mb of the major genes.
  3. cBold, SNPs within 1 Mb of the major genes.