|
Study source
|
US Microsa
|
US-SNPsb
|
Canada Affymetrix
|
Canada Illuminac
|
France
|
UK Cohort 1d
|
UK Cohort 2e
|
|---|
|
Ascertainment criteria
|
2 ACR+ sibs, 1 with erosions
|
2 ACR+ sibs, 1 with erosions
|
2 ACR+ sibs
| |
2 ACR+ sibs
|
2 ACR+ sibs
|
2 ACR+ sibs
|
|---|
|
Number of families
|
511
|
757
|
79
|
60
|
88
|
174
|
195
|
|
Affected sibs/family
|
2.13
|
2.15
|
2
|
2
|
2.18
|
2.13
|
2.09
|
|
% SE+
|
71%
|
79%
|
N/A
|
N/A
|
N/A
|
90%
|
82%
|
|
% Erosion
|
95%
|
97%
|
39%
|
N/A
|
N/A
|
76%
|
71%
|
|
Median age onset
|
39.1
|
38.9
|
43.8
|
N/A
|
N/A
|
39.3
|
44.0
|
|
% RF+
|
81.1%
|
74.3%
|
71.1%
|
N/A
|
N/A
|
62.5%
|
56.7%
|
- aNumbers from Jawaheer et al. [17]. One family was eliminated from GAW15 data because one sib did not meet ACR criteria for RA.
- bOf these families, 9 had only phenotype information and no SNP genotypes, 509 families have both SNP and microsatellite data, 2 families have microsatellite data only, and 237 have SNP data only.
- c47 families have genotype data using both Affymetrix and Illumina platforms.
- d174 affected families had microsatellite data and of these 157 also had SNP genotyping.
- eSelected microsatellite markers were genotyped for variable numbers of these families.
