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Table 1 Distribution of selected clinical characteristics among study participants from rheumatoid arthritis studies for GAW15 Problem 2

From: Data for Genetic Analysis Workshop (GAW) 15 Problem 2, genetic causes of rheumatoid arthritis and associated traits

Study source US Microsa US-SNPsb Canada Affymetrix Canada Illuminac France UK Cohort 1d UK Cohort 2e
Ascertainment criteria 2 ACR+ sibs, 1 with erosions 2 ACR+ sibs, 1 with erosions 2 ACR+ sibs   2 ACR+ sibs 2 ACR+ sibs 2 ACR+ sibs
Number of families 511 757 79 60 88 174 195
Affected sibs/family 2.13 2.15 2 2 2.18 2.13 2.09
% SE+ 71% 79% N/A N/A N/A 90% 82%
% Erosion 95% 97% 39% N/A N/A 76% 71%
Median age onset 39.1 38.9 43.8 N/A N/A 39.3 44.0
% RF+ 81.1% 74.3% 71.1% N/A N/A 62.5% 56.7%
  1. aNumbers from Jawaheer et al. [17]. One family was eliminated from GAW15 data because one sib did not meet ACR criteria for RA.
  2. bOf these families, 9 had only phenotype information and no SNP genotypes, 509 families have both SNP and microsatellite data, 2 families have microsatellite data only, and 237 have SNP data only.
  3. c47 families have genotype data using both Affymetrix and Illumina platforms.
  4. d174 affected families had microsatellite data and of these 157 also had SNP genotyping.
  5. eSelected microsatellite markers were genotyped for variable numbers of these families.