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Table 1 Genome screen results (LOD scores) for replicate 1

From: A two-stage classification approach identifies seven susceptibility genes for a simulated complex disease

 

Chromosome [Location (cM)]

Trait (any covariates included)

6 (49 cM)

8 (169 cM)

9 (50 cM)

11 (115 cM)

18 (94 cM)

Affection status

     

   Mapmaker/SIBS

50.4

    

AgeAtOnset (including gender)

     

   Haseman-Elston

 

3.1

4.4

  

   SOLAR

 

4.2

4.5

  

Severity

     

   Haseman-Elston

 

8.6

9.6

  

   SOLAR

 

9.0

7.5

  

Anti-CCP† (including gender)

     

   Haseman-Elston

5.4

   

(1.8)

   SOLAR

4.9†

   

(2.2)

Anti-CCP† (including gender and DR alleles)

     

   Haseman-Elston

(1.0)

   

3.3

   SOLAR

(1.3)

   

3.8†

Anti-CCP transformed (including covariates)

     

   Haseman-Elston

(0.5)

   

5.1

   SOLAR

(1.2)

   

7.9

IgM†(including gender and smoking history)

     

   Haseman-Elston

   

(1.2)

 

   SOLAR

   

4.9†

 

IgM transformed (including covariates)

     

   Haseman-Elston

   

10.8

 

   SOLAR

   

22.4

 
  1. †Results from SOLAR for these untransformed variables should not be considered valid because these trait distributions had high levels of kurtosis and were the only ones to yield a lot of noise (additional findings on other chromosomes with LOD scores approaching and exceeding 3.0 that are assumed to be false positives).
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BMC Proceedings

ISSN: 1753-6561

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