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Table 1 Genome screen results (LOD scores) for replicate 1

From: A two-stage classification approach identifies seven susceptibility genes for a simulated complex disease

  Chromosome [Location (cM)]
Trait (any covariates included) 6 (49 cM) 8 (169 cM) 9 (50 cM) 11 (115 cM) 18 (94 cM)
Affection status      
   Mapmaker/SIBS 50.4     
AgeAtOnset (including gender)      
   Haseman-Elston   3.1 4.4   
   SOLAR   4.2 4.5   
Severity      
   Haseman-Elston   8.6 9.6   
   SOLAR   9.0 7.5   
Anti-CCP† (including gender)      
   Haseman-Elston 5.4     (1.8)
   SOLAR 4.9†     (2.2)
Anti-CCP† (including gender and DR alleles)      
   Haseman-Elston (1.0)     3.3
   SOLAR (1.3)     3.8†
Anti-CCP transformed (including covariates)      
   Haseman-Elston (0.5)     5.1
   SOLAR (1.2)     7.9
IgM†(including gender and smoking history)      
   Haseman-Elston     (1.2)  
   SOLAR     4.9†  
IgM transformed (including covariates)      
   Haseman-Elston     10.8  
   SOLAR     22.4  
  1. †Results from SOLAR for these untransformed variables should not be considered valid because these trait distributions had high levels of kurtosis and were the only ones to yield a lot of noise (additional findings on other chromosomes with LOD scores approaching and exceeding 3.0 that are assumed to be false positives).