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Table 2 Classification results

From: A two-stage classification approach identifies seven susceptibility genes for a simulated complex disease

 

Logistic regression

 

MDR testing accuracy

Maximized accuracy

Nagelkerke R2

Factors

Before undertaking genetic analyses

82.6%

84.3%

0.652

Number of DR 3 alleles

85.7%

85.7%

0.683

Number of DR 3 alleles, sex, smoked

Using results from first round of genetic analyses

86.5%

86.4%

0.705

Number of DR 3 alleles, sex, smoked, SNP11_389, SNP18_269

Using results from second round of genetic analyses

88.4%

88.5%

0.715

Number of DR 3 alleles, sex, SNP6_154, SNP6_162

88.2%

88.5%

0.746

+Smoked, SNP11_389, SNP18_269

Using SNPs/SNP haplotypes nearest the underlying loci as described in the "answers"

88.5%

88.5%

0.746

The SNPs nearest loci A-F, sex, smoking, DR genotype

Using the underlying loci provided in the "answers"

88.7%

90.1%

0.773

Number of deleterious alleles at loci A-F, sex, smoking, DR