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Table 3 Single-SNP case-control analysis for SNPs in 14 candidate genes

From: Case-control association analysis of rheumatoid arthritis with candidate genes using related cases

   Minor Allele Frequencies p-valuesa
   Cases Controls   
Gene dbSNP ID Affected Siblingb (n = 816) One Sibling per Familyc (n = 461) (n = 855) Affected Siblingb One Sibling per Familyc
PTPN22 Rs2476601 0.163 0.156 0.084 2.13 × 10-10 4.96 × 10-8
CTLA4 Rs3087243 0.447 0.407 0.447 0.01016 0.04618
HAVCR1 Rs6149307 0.17 0.174 0.142 0.03939 0.03193
HAVCR1 5509_5511 delCAA 0.195 0.200 0.235 0.01834 0.05172
SUMO4 Rs237025 0.517 0.520 0.456 0.00154 0.00202
SUMO4 Rs577001 0.391 0.387 0.350 0.02512 0.06162
  1. ap-Values were not adjusted for the multiple testing. Only significant results are presented in the table.
  2. bAllele frequencies and p-values were obtained using all cases and unrelated controls.
  3. cAllele frequencies and p-values were obtained using one randomly selected case per family and unrelated controls.