Table 1 Type I error rates and power (in percentage) for testing association in the presence of linkage (T1)
From: Joint modeling of linkage and association using affected sib-pair data
LD group (number of SNPs) | ||||||
|---|---|---|---|---|---|---|
Significance level (%) | r2 = 0 (n = 947) | 0 <r2 <= 0.01 (n = 1751) | 0.01 <r2 <= 0.1 (n = 304) | 0.1 <r2 <= 0.3 (n = 29) | 0.3 <r2 <= 0.92 (n = 18) | |
FBAT-e | 5 | 4.9 | 29.1 | 90.4 | 100 | 100 |
1 | 1 | 18.4 | 85.3 | 100 | 100 | |
0.1 | 0.1 | 10.4 | 77.2 | 99.9 | 100 | |
Millstein-b | 5 | 4.9 | 28.6 | 90.1 | 100 | 100 |
1 | 1 | 18 | 84.9 | 100 | 100 | |
0.1 | 0.1 | 10.1 | 76.6 | 99.9 | 100 | |
LAMP-LE | 5 | 4.3 | 22.5 | 87.8 | 100 | 100 |
1 | 0.9 | 14.3 | 81.8 | 100 | 100 | |
0.1 | 0.1 | 8.2 | 73.4 | 99.8 | 100 | |
TDT | 5 | 5.1 | 29.9 | 90.7 | 100 | 100 |
1 | 1.1 | 19.1 | 85.9 | 100 | 100 | |
0.1 | 0.1 | 11 | 78.1 | 99.9 | 100 | |
HST-LE | 5 | 5.2 | 5.9 | 21.3 | 49.9 | 86.9 |
1 | 1.1 | 1.4 | 10.3 | 41.8 | 79.5 | |
0.1 | 0.1 | 0.2 | 4.1 | 34.1 | 74.9 | |
HSTDT | 5 | 7.3 | 29.2 | 90.2 | 100 | 100 |
1 | 1.9 | 18.6 | 85.3 | 100 | 100 | |
0.1 | 0.3 | 11 | 77.9 | 99.8 | 100 | |