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Table 1 p-Values for various methods used for testing for genetic association

From: A new score statistic to test for association given linkage in affected sibling pair-control designs

Replicate Number of pairs μ a δ b P-values for testing association in ASP-controlsc P-values of various statistics for testing association given linkage
      Ud in ASP-controls U*e in ASP-controls LR statisticf in ASP-controls LR statisticf in ASP
1 229 0.31 0.34 5.6 × 10-5 1.8 × 10-5 2.2 × 10-8 8.0 × 10-5 0.4
2 225 0.34 0.24 1.4 × 10-6 3.1 × 10-6 1.2 × 10-9 7.0 × 10-5 0.8
3 223 0.32 0.31 1.1 × 10-4 1.4 × 10-4 1.0 × 10-7 7.1 × 10-4 0.6
4 214 0.33 0.27 8.8 × 10-4 1.2 × 10-3 1.8 × 10-5 0.009 0.6
5 244 0.35 0.23 1.0 × 10-3 1.7 × 10-3 5.6 × 10-5 0.008 0.2
  1. aExpectation of number of DR1 alleles carried by an individual
  2. bKong and Cox δ [4]
  3. cThe dependency of the genotypes of siblings is taken into account by using the empirical variance
  4. dNew score statistic
  5. eModified version of U obtained by combining siblings with IBD = 1 and IBD = 2
  6. fLikelihood ratio statistic of LAMP comparing the models GM and LE [2]