Skip to main content

Table 1 p-Values for various methods used for testing for genetic association

From: A new score statistic to test for association given linkage in affected sibling pair-control designs

Replicate

Number of pairs

μ a

δ b

P-values for testing association in ASP-controlsc

P-values of various statistics for testing association given linkage

     

Ud in ASP-controls

U*e in ASP-controls

LR statisticf in ASP-controls

LR statisticf in ASP

1

229

0.31

0.34

5.6 × 10-5

1.8 × 10-5

2.2 × 10-8

8.0 × 10-5

0.4

2

225

0.34

0.24

1.4 × 10-6

3.1 × 10-6

1.2 × 10-9

7.0 × 10-5

0.8

3

223

0.32

0.31

1.1 × 10-4

1.4 × 10-4

1.0 × 10-7

7.1 × 10-4

0.6

4

214

0.33

0.27

8.8 × 10-4

1.2 × 10-3

1.8 × 10-5

0.009

0.6

5

244

0.35

0.23

1.0 × 10-3

1.7 × 10-3

5.6 × 10-5

0.008

0.2

  1. aExpectation of number of DR1 alleles carried by an individual
  2. bKong and Cox δ [4]
  3. cThe dependency of the genotypes of siblings is taken into account by using the empirical variance
  4. dNew score statistic
  5. eModified version of U obtained by combining siblings with IBD = 1 and IBD = 2
  6. fLikelihood ratio statistic of LAMP comparing the models GM and LE [2]
Back to article page

BMC Proceedings

ISSN: 1753-6561

Contact us