A new score statistic to test for association given linkage in affected sibling pair-control designs

BMC Proceedings

Table 2 Number of times H₀ is rejected using the various methods of testing for genetic association

			Testing for association given linkage
Replicates	Significance level	Testing association in ASP-controls^a	U^b in ASP-controls	U*^c in ASP-controls	LR statistic^d in ASP-controls	LR statistic^d in ASP
1 to 100	0.05	100	100	100	100	42
1 to 100	0.001	93	91	97	98	5

^aThe dependency of the genotypes of siblings is taken into account by using the empirical variance
^bNew score statistic
^cModified version of U obtained by combining siblings with IBD = 1 and IBD = 2
^dLikelihood ratio statistic of LAMP comparing the models GM and LE [2]

ISSN: 1753-6561