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Table 2 Mean LOD scores for the three tests summarized from 100 replicates

From: Identifying single-nucleotide polymorphisms responsible for the linkage signal of rheumatoid arthritis on chromosome 6 by joint modeling of linkage and association

  Test for linkage Test for association in the presence of linkage Test for other linked variants
Models compared LE vs. BM GM vs. LE GM vs. LD
d.f. 4 - 1 = 3 5 - 4 = 1 5 - 3 = 2
SNP6_153    With flanking markers Without flanking markers
   ASPs+controls   705.3
(range: 653.1–763.0)
7.8
(range: 2.2–17.9)
(powera: 100%)
6.8
(range: 1.8–15.5)
(power: 100%)
   ASPs 132.3
(range: 105.9–152.9)
441.9
(range: 401.3–485.8)
4.1
(range: 0.8–12.6)
(power: 94%)
1.7
(range: 0.0–5.3)
(power: 53%)
SNP6_162     
   ASPs+controls   44.4
(range: 30.0–62.2)
59.1
(range: 39.5–81.1)
(power: 100%)
2.0
(range: 0.0–6.3)
(power: 63%)
   ASPs 9.1
(range: 3.4–15.8)
27.8
(range: 14.8–41.3)
58.9
(range: 39.7–81.0)
(power: 100%)
1.8
(range: 0.0–6.1)
(power: 55%)
  1. aPower based on significance level of 0.05 and asymptotic chi-square distribution.