BMC Proceedings

Table 2 Empirical type I error rate at a nominal 0.05 significance level and power at an estimated 0.05 significance level under various assumed genetic models, based on 500 replicate samples

From: A logistic mixture model for a family-based association study

	Analysis model
	Dominant				Recessive				Additive
	SEGREG		ASSOC		SEGREG		ASSOC		SEGREG		ASSOC
Simulation model	Type I error	Power	Type I error	Power	Type I error	Power	Type I error	Power	Type I error	Power	Type I error	Power
D3	0.006	0.828	0.006	0.818	0.014	0.074	0.010	0.080	0.000	0.530	0.000	0.524
D6	0.016	0.988	0.016	0.986	0.030	0.062	0.018	0.056	0.004	0.852	0.004	0.824
D9	0.004	1.000	0.004	1.000	0.022	0.058	0.022	0.068	0.004	0.940	0.002	0.914
R3	0.004	0.036	0.004	0.036	0.030	0.646	0.024	0.706	0.006	0.450	0.004	0.468
R6	0.008	0.030	0.010	0.028	0.020	0.998	0.022	1.000	0.002	0.978	0.004	0.982
R9	0.016	0.064	0.016	0.056	0.018	1.000	0.018	1.000	0.010	0.996	0.012	1.000
A3	0.012	0.468	0.012	0.462	0.022	0.232	0.020	0.250	0.001	0.552	0.002	0.546
A6	0.008	0.844	0.008	0.838	0.030	0.324	0.022	0.352	0.012	0.874	0.012	0.854
A9	0.010	0.944	0.014	0.936	0.016	0.550	0.010	0.574	0.001	0.962	0.004	0.960

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ISSN: 1753-6561

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