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Table 1 Comparison of SNPs linked versus those associated with 3550 phenotypes

From: An empirical evaluation of the common disease-common variant hypothesis

Thresholds SNP categorya   Minor allele frequencies β Coefficients (for associated SNPs)
Phenotypes Linkage (LOD) Assoc (Z) A L Number Range Median Mean Range Median Mean
3550 4.99 6.66 + + 6 0.01–0.02 0.01 0.01 2.4–5.7 4.7 4.4
    + - 221 0.01–0.5 0.01 0.03 0.36–5.5 3.8 3.5
    - + 15970 0.01–0.5 0.24 0.25    
    - - 510738 0.01–0.5 0.23 0.25    
355b 4.03 6.32 + + 12 0.01–0.38 0.02 0.05 0.4–5.7 3.5 3.3
    + - 293 0.01–0.5 0.01 0.04 0.3–5.4 3.2 3.1
    - + 19276 0.01–0.5 0.23 0.25    
    - - 507354 0.01–0.5 0.23 0.25    
108c 3.54 6.13 + + 21 0.01–0.38 0.02 0.06 0.27–5.7 2.4 2.7
    + - 335 0.01–0.5 0.01 0.04 0.16–5.4 3.2 3.1
    - + 29387 0.01–0.5 0.23 0.25    
    - - 497192 0.01–0.5 0.23 0.25    
3550 3.3d 5.34d + + 82 0.01–0.5 0.07 0.12 0.2–5.7 1.1 1.6
    + - 1118 0.01–0.5 0.06 0.12 0.16–5.7 1.3 1.7
    - + 36239 0.01–0.5 0.23 0.25    
    - - 489496 0.01–0.5 0.23 0.25    
  1. a A denotes a significant association, L denotes a significant linkage
  2. b Most heritable phenotypes (10%).
  3. c Phenotypes with >50% heritablility.
  4. d Relaxed thresholds: alpha levels do not account for testing of multiple phenotypes