Comparison between LR analysis and RF importance measures. a/A, Single marker additive (a) and pairwise interaction effects (A) by LR using the median-replaced data. Upper left of A depicts the interaction-specific analysis, lower right the full LR interaction model. b/B, RF single (b) and joint (B) marker importance analysis based on 500 trees using the median-replaced data. Both triangles of B are identical. c/C, same as a/A using five imputed data sets (rs2240340 was excluded). d/D, same as b/B using five imputed data sets (rs2240340 was excluded). Markers with p ≤ 10-8 were truncated to p = 10-8; All presented p-values are uncorrected for multiple testing.