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Table 1 Median and interquartile range of variable rankings and importance measures on simulated interacting risk factors

From: Stability of variable importance scores and rankings using statistical learning tools on single-nucleotide polymorphisms and risk factors involved in gene × gene and gene × environment interactions

  GBM MCLR RF
  Median ranking Ranking interquartile range Median importance Importance interquartile range Median ranking Ranking interquartile range Median importancea Importance interquartile rangea Median ranking Ranking interquartile range Median importance Importance interquartile range
Chromosome 6, SNP A, Dominant 1 No variation 43.18 43.08–43.27 4 3–4 1 No variation 2 2–3 110.5 106.8–113.4
Chromosome 6, SNP A, Recessive 3 No variation 9.23 9.20–9.25 3 2–3 1 No variation 4 No variation 55 53.0–57.1
Chromosome 6, SNP B, Dominant 2 No variation 39.02 38.94–39.14 5 4–5 1 No variation 3 2–3 108 105.1–110.4
Chromosome 6, SNP B, Recessive -- b -- -- -- 256 217–300 0.0009628 0.0008214–0.001118 6 No variation 23.4 22.5–24.4
Chromosome 8, Disease Locus, Dominant 13 12–13 0.07 0.065–0.075 7 6–7 0.9998 0.9921–1 14 No variation 2.6 2.5–2.6
Chromosome 8, Disease Locus, Recessive -- -- -- -- 21 11–44 0.0105 0.003999–0.428 1322 1079–1533 0.57 0.53–0.61
Chromosome 16, Disease Locus, Dominant -- -- -- -- 624 525–716 0.0004029 0.0003219–0.0004992 51 40–75 0.85 0.81–0.91
Chromosome 16, Disease Locus, Recessive 11 No variation 0.087 0.083–0.093 2027 1757–2305 0.0000826 5.63e-5-0.0001214 31 29–32 1.05 1.01–0.12
Sex 5 No variation 1.975 1.96–1.99 2 2–6 0.9998 0.9921–1 8 No variation 11.8 11.6–12.4
Smoking 4 No variation 2.35 2.34–2.36 20 10–43 0.0105 0.003999–0.428 10 No variation 6.8 6.6–7.1
  1. aProportion of times variable selected out of 10,000,000 moves in the Markov chain.
  2. bVariable had importance = 0 for median and first and third quartile, so it was not ranked.