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Table 1 The number of GA evaluations to obtain one of the ten most significant interactions

From: Identification of expression quantitative trait loci by the interaction analysis using genetic algorithm

 

SNP1

SNP2

   

Expressed gene

rs number

Gene

Chr

rs number

Gene

Chr

p-Value

Generations

Evaluations

EP300

rs1037782

LOC441716

15q13.1

rs1274224

ZBTB20

3q13.2

8.97 × 10-7

11

11000

 

rs616113

CACNA2D3

3p21.1

rs312926

BRUNOL5

19p13

2.01 × 10-6

20/8a

20000/8000a

 

rs1909160

 

12

rs1824780

 

5

2.23 × 10-6

28/7/37a

28000/7000/37000a

 

rs2219328

 

3

rs721602

 

12

2.46 × 10-6

7

7000

 

rs1909160

 

12

rs1463234

 

3

4.33 × 10-6

9/46a

9000/46000a

 

rs627953

 

18

rs1537375

LOC401495

9

9.89 × 10-6

15

15000

BRCA1

rs1037782

 

15

rs1274224

ZBTB20

3q13.2

8.97 × 10-7

26/27/11/21a

26000/27000/11000/21000a

 

rs1025048

 

5

rs1430509

 

4

4.33 × 10-7

22/12a

22000/12000a

 

rs1861478

 

12

rs1391708

 

12

7.47 × 10-7

46

46000

 

rs2215054

KIAA0672

17p12

rs179562

 

14

8.15 × 10-7

6

6000

 

rs2215054

KIAA0672

17p12

rs593418

 

18

4.01 × 10-7

10

10000

 

rs2215054

KIAA0672

17p12

rs179562

 

14

8.15 × 10-7

38

38000

TAF15

rs2180052

 

6

rs1798294

 

12

8.49 × 10-9

74/12a

74000/12000a

 

rs1798294

 

12

rs564021

 

18

4.11 × 10-9

33

33000

 

rs1798294

 

12

rs1480691

SGCZ

8p22

1.6 × 10-9

32

32000

 

rs766083

FER1L3

10q24

rs2040692

 

22

5.53 × 10-9

68

68000

 

rs1798294

 

12

rs1524163

NR5A2

1q32.1

5.43 × 10-9

12

12000

 

rs1798294

 

12

rs1548543

 

19

6.21 × 10-10

25/11/11/40a

25000/11000/11000/40000a

  1. aSNP pairs are identified from more than two runs.