Identifying cis- and trans-acting single-nucleotide polymorphisms controlling lymphocyte gene expression in humans

Table 1 Distribution of the number of expression phenotypes with different number of SNPs in the regression models of steps 1 and 3 of our three-step method

Step	No. SNPs	0	1	2	3	4	5	6	7	8	9	≥10
1	Available^a	1286	413	310	614	417	148	169	59	16	16	14
	AIC^b	1286	1697	350	107	17	3	1	1	0	0	0
	p ≤ 0.01^c		245	43	0	0	0	0	0	0	0	0
	p ≤ 0.001^c		88	5	0	0	0	0	0	0	0	0
3	Linkages^d	294	81	76	118	141	102	101	102	110	91	2264
	AIC	294	664	362	295	270	236	187	147	127	101	645
	p ≤ 0.01^c		930	433	188	101	58	38	21	11	11	32
	p ≤ 0.001^c		572	151	60	25	12	10	3	6	2	2

^a"Available" denotes the number of phenotypes with the given number of available cis-SNPs in Step 1.
^b"AIC" denotes the number of phenotypes where the given number of SNPs was retained by the stepwise linear regression model.
^cThe number of phenotypes among those in the previous line in which the p-values of SNP associated with the phenotypes are less than or equal to the given significance level.
^d"Linkages" denotes the number of phenotypes linked (LOD > 2.0) to the given number of SNPs.

ISSN: 1753-6561