| | | | | |
Model 3e
|
Model 4f
|
Mantel
|
---|
|
MAFa
|
D'b
|
r
2b
|
Model 1c
|
Model 2d
|
Main
|
Interaction
|
Main
|
Interaction
|
M(0) (main effect)
|
M(1) (joint effect)
|
---|
SNP1
|
0.32
|
1
|
0.16
|
1
|
1
|
0.28
|
0
|
0.02
|
0.01
|
1.00
|
1.00
|
SNP2
|
0.12
|
1
|
0.04
|
0.99
|
0.99
|
0.06
|
0
|
0.01
|
0.01
|
1.00
|
1.00
|
SNP3
|
0.37
|
0.95
|
0.17
|
1
|
1
|
0.48
|
0.01
|
0.02
|
0.01
|
1.00
|
1.00
|
SNP4
|
0.49
|
1
|
0.34
|
1
|
1
|
0.37
|
0
|
0.02
|
0.01
|
1.00
|
1.00
|
SNP5
|
0.05
|
0.21
|
0
|
0.01
|
0.01
|
0
|
0.01
|
0.01
|
0.01
|
1.00
|
1.00
|
SNP6
|
0.13
|
1
|
0.05
|
1
|
1
|
0.08
|
0
|
0.01
|
0.01
|
1.00
|
1.00
|
SNP7
|
0.13
|
1
|
0.05
|
1
|
1
|
0.08
|
0
|
0.01
|
0
|
1.00
|
1.00
|
SNP8
|
0.23
|
1
|
0.1
|
1
|
1
|
0.36
|
0
|
0.02
|
0.02
|
1.00
|
1.00
|
SNP9
|
0.23
|
1
|
0.1
|
1
|
1
|
0.36
|
0
|
0
|
0
|
1.00
|
1.00
|
SNP10
|
0.41
|
0.94
|
0.41
|
1
|
1
|
0.51
|
0.01
|
0.05
|
0.01
|
1.00
|
1.00
|
DR locus
|
0.25
|
1
|
1
|
1
|
1
|
0.44
|
0.01
|
0.14
|
0.01
|
1.00
|
1.00
|
Locus C
|
0.42
|
1
|
0.45
|
1
|
1
|
0.2
|
0.01
|
0.04
|
0.01
|
1.00
|
1.00
|
SNP13
|
0.4
|
1
|
0.22
|
1
|
1
|
0.42
|
0.01
|
0.09
|
0.02
|
1.00
|
1.00
|
SNP14
|
0.33
|
0.99
|
0.65
|
1
|
1
|
0.4
|
0.03
|
0.03
|
0.01
|
1.00
|
1.00
|
SNP15
|
0.48
|
0.93
|
0.3
|
0.15
|
0.07
|
0
|
0
|
0.01
|
0.01
|
1.00
|
1.00
|
SNP16
|
0
|
0.92
|
0
|
1
|
1
|
0.56
|
0
|
0.02
|
0.01
|
1.00
|
1.00
|
SNP17
|
0.24
|
0.98
|
0.92
|
1
|
0.99
|
0.03
|
0
|
0.01
|
0.01
|
1.00
|
1.00
|
SNP18
|
0.1
|
1
|
0.04
|
1
|
0.99
|
0.07
|
0
|
0.01
|
0.01
|
1.00
|
1.00
|
SNP19
|
0.12
|
1
|
0.05
|
1
|
1
|
0.12
|
0
|
0.01
|
0.01
|
1.00
|
1.00
|
SNP20
|
0.39
|
0.56
|
0.07
|
1
|
1
|
0.52
|
0
|
0.01
|
0.01
|
1.00
|
1.00
|
SNP21
|
0.47
|
0.94
|
0.26
|
1
|
1
|
0
|
0.02
|
0.01
|
0.01
|
1.00
|
1.00
|
SNP22
|
0.1
|
0.71
|
0.02
|
1
|
1
|
0.33
|
0
|
0.07
|
0.01
|
1.00
|
1.00
|
- Power is the percentage of replicates in which the main or interaction effect of the respective marker had an adjusted p-value ≤ 0.05.
- aMinor allele frequency among controls
- bLD values calculated using the control population in Replicate 1
- cModel 1, main effect of one SNP at a time
- dModel 2, interaction term with sex of one SNP at a time
- eModel 3, main and interaction with sex of one SNP at a time
- fModel 4, stepwise model with main and interaction effects of all SNPs