Table 3 Power for the CLR and Mantel statistic using 500 case-control pairs
Model 3e | Model 4f | Mantel | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
MAFa | D'b | r 2b | Model 1c | Model 2d | Main | Interaction | Main | Interaction | M(0) (main effect) | M(1) (joint effect) | |
SNP1 | 0.32 | 1 | 0.16 | 1 | 1 | 0.28 | 0 | 0.02 | 0.01 | 1.00 | 1.00 |
SNP2 | 0.12 | 1 | 0.04 | 0.99 | 0.99 | 0.06 | 0 | 0.01 | 0.01 | 1.00 | 1.00 |
SNP3 | 0.37 | 0.95 | 0.17 | 1 | 1 | 0.48 | 0.01 | 0.02 | 0.01 | 1.00 | 1.00 |
SNP4 | 0.49 | 1 | 0.34 | 1 | 1 | 0.37 | 0 | 0.02 | 0.01 | 1.00 | 1.00 |
SNP5 | 0.05 | 0.21 | 0 | 0.01 | 0.01 | 0 | 0.01 | 0.01 | 0.01 | 1.00 | 1.00 |
SNP6 | 0.13 | 1 | 0.05 | 1 | 1 | 0.08 | 0 | 0.01 | 0.01 | 1.00 | 1.00 |
SNP7 | 0.13 | 1 | 0.05 | 1 | 1 | 0.08 | 0 | 0.01 | 0 | 1.00 | 1.00 |
SNP8 | 0.23 | 1 | 0.1 | 1 | 1 | 0.36 | 0 | 0.02 | 0.02 | 1.00 | 1.00 |
SNP9 | 0.23 | 1 | 0.1 | 1 | 1 | 0.36 | 0 | 0 | 0 | 1.00 | 1.00 |
SNP10 | 0.41 | 0.94 | 0.41 | 1 | 1 | 0.51 | 0.01 | 0.05 | 0.01 | 1.00 | 1.00 |
DR locus | 0.25 | 1 | 1 | 1 | 1 | 0.44 | 0.01 | 0.14 | 0.01 | 1.00 | 1.00 |
Locus C | 0.42 | 1 | 0.45 | 1 | 1 | 0.2 | 0.01 | 0.04 | 0.01 | 1.00 | 1.00 |
SNP13 | 0.4 | 1 | 0.22 | 1 | 1 | 0.42 | 0.01 | 0.09 | 0.02 | 1.00 | 1.00 |
SNP14 | 0.33 | 0.99 | 0.65 | 1 | 1 | 0.4 | 0.03 | 0.03 | 0.01 | 1.00 | 1.00 |
SNP15 | 0.48 | 0.93 | 0.3 | 0.15 | 0.07 | 0 | 0 | 0.01 | 0.01 | 1.00 | 1.00 |
SNP16 | 0 | 0.92 | 0 | 1 | 1 | 0.56 | 0 | 0.02 | 0.01 | 1.00 | 1.00 |
SNP17 | 0.24 | 0.98 | 0.92 | 1 | 0.99 | 0.03 | 0 | 0.01 | 0.01 | 1.00 | 1.00 |
SNP18 | 0.1 | 1 | 0.04 | 1 | 0.99 | 0.07 | 0 | 0.01 | 0.01 | 1.00 | 1.00 |
SNP19 | 0.12 | 1 | 0.05 | 1 | 1 | 0.12 | 0 | 0.01 | 0.01 | 1.00 | 1.00 |
SNP20 | 0.39 | 0.56 | 0.07 | 1 | 1 | 0.52 | 0 | 0.01 | 0.01 | 1.00 | 1.00 |
SNP21 | 0.47 | 0.94 | 0.26 | 1 | 1 | 0 | 0.02 | 0.01 | 0.01 | 1.00 | 1.00 |
SNP22 | 0.1 | 0.71 | 0.02 | 1 | 1 | 0.33 | 0 | 0.07 | 0.01 | 1.00 | 1.00 |