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Table 4 Power of the haplotype-trait association test using 500 case-control pairs

From: Comparison of the power of haplotype-based versus single- and multilocus association methods for gene × environment (gene × sex) interactions and application to gene × smoking and gene × sex interactions in rheumatoid arthritis

Common haplotypesa Frequencyb Model 1c (main effects of haplotypes) Model 2c (main effects and haplotype-sex interaction effects)
    Main Interaction
21221111121 22221211221 0.06 1 0.95 0.78
1111111111 3 1 1111111211 0.07 0.99 0.82 0.66
21221111121 22221211121 0.11 1 0.99 0.65
1111111111 3 1 1111111111 (reference haplotype) 0.39    
  1. a Haplotypes present in at least 80 replicates of the 100 replicates (risk loci are underlined, DR locus italicized, C locus not italicized), including the alleles at the 22 loci
  2. b Estimated haplotype frequencies (combined sample) in the 100 replicates
  3. c Power is the percentage of replicates in which the main or interaction effect of the respective haplotype had an adjusted p-value of ≤ 0.05.