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Table 5 Adjusted p-values for the haplotype-trait association test in PTPN22

From: Comparison of the power of haplotype-based versus single- and multilocus association methods for gene × environment (gene × sex) interactions and application to gene × smoking and gene × sex interactions in rheumatoid arthritis

    Model 2 (main effects and haplotype-sex interaction effects) Model 2 (main effects and haplotype-smoking interaction effects)
Common haplotypes in the investigated regionsa Frequency Model 1 (main effects of haplotypes) Main Interaction w/sex Main Interaction w/smoking
3 3 1 1 1 1 1 2 3 4 4 2 2 3 0.19 0.25 0.67 0.58 0.97 1
4 1 1 1 1 1 3 2 3 4 2 2 2 1 0.09 0.2 0.89 0.98 0.91 0.78
4 1 1 1 1 1 3 2 3 4 4 2 2 1 0.09 0.44 0.07 0.04 b 0.91 0.93
4 1 3 1 3 1 1 2 1 4 4 2 4 3 0.12 <0.001 0.6 0.15 0.17 0.82
4 1 3 1 3 1 1 2 3 4 4 2 4 3 0.12 0.44 0.98 0.98 0.97 1
4 1 1 1 1 1 3 2 3 2 4 4 2 3 0.27      
(reference haplotype)       
  1. Loci in the table are listed as described in Table 4.
  2. aEstablished risk locus R620W is bold, underlined
  3. bp-Values ≤ 0.05 are given in bold.