Table 1 Suggestive linkage regions detected by RP model

Marker name (DECODE)

NPL p-value

Overall RP asymptotic p-value

Overall RP empirical p-value

Splitting covariates

Subgroup with largest likelihood ratio

λ₁ and λ₂ for this subgroup

H35a (102.02 cM)

0.62

0.0073

0.045

HLA-DRB1

Both without *04 allele in HLA-DRB1

0.82, 0.35

H19a (109.04 cM)

0.16

0.0014

0.016

HLA-DRB1

Both without *04 allele in HLA-DRB1

0.83, 0.40

F19b (113.69 cM)

0.23

0.0049

0.036

HLA-DRB1

Both without *04 allele in HLA-DRB1

0.84, 0.44

H8c (125.51 cM)

0.13

0.0040

0.035

HLA-DRB1

At least one has *04 allele in HLA-DRB1

1.14, 1.50

F27b (239.66 cM)

0.05

0.0006

0.009

Age at onset

Both age at onset less than median

1.34, 2.23