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Table 1 Suggestive linkage regions detected by RP model

From: Evidence of linkage to chromosome 1 for early age of onset of rheumatoid arthritis and HLA marker DRB1 genotype in NARAC data

Marker name (DECODE) NPL p-value Overall RP asymptotic p-value Overall RP empirical p-value Splitting covariates Subgroup with largest likelihood ratio λ1 and λ2 for this subgroup
H35a (102.02 cM) 0.62 0.0073 0.045 HLA-DRB1 Both without *04 allele in HLA-DRB1 0.82, 0.35
H19a (109.04 cM) 0.16 0.0014 0.016 HLA-DRB1 Both without *04 allele in HLA-DRB1 0.83, 0.40
F19b (113.69 cM) 0.23 0.0049 0.036 HLA-DRB1 Both without *04 allele in HLA-DRB1 0.84, 0.44
H8c (125.51 cM) 0.13 0.0040 0.035 HLA-DRB1 At least one has *04 allele in HLA-DRB1 1.14, 1.50
F27b (239.66 cM) 0.05 0.0006 0.009 Age at onset Both age at onset less than median 1.34, 2.23