Skip to main content

Table 1 Expression phenotypes with the strongest agreement and evidence of linkage for the Morley et al. [2], single-probe, and principal-components analyses

From: Linkage analysis using principal components of gene expression data

    Morley et al. [2] Single probe Principal components
Gene Location Probe p-value LOD p-value Position (cM) PC LOD p-value Position (cM)
CH13L2 1p13.3 213060.s.at <10-10 11.6 <10-12 111.8 3 2.9 <10-3 112.2
ZP3 7q11 210910.at <10-9 13 <10-14 75.6 4 2.9 <10-3 64.3
PSPHL 7p11 205048.s.at <10-10 6.1 <10-7 64.3 4 2.9 <10-3 64.3
DDX17 22q13 208151x.at <10-9 5.9 <10-7 43.4 5 1.2 <10-2 47.7
UGT2B17 4q13 207245.at --------- 8.3 <10-9 62.3 2 7.1 <10-8 63.9
LRAP 5q15 219759.at --------- 8.1 <10-9 99 4 5.6 <10-6 97.7
HLA-DQB1 6p21.3 209480.at --------- 9 <10-10 36 1 10.7 <10-11 34.2
HLA-DPB1 6p21.3 201137.s.at --------- 8.8 <10-10 31.6 3 3.8 <10-4 38.3
  1. The column "LOD" represents the maximum LOD scores in the chromosome where the genes are located with its respective p-values and positions in cM. The principal components results represent values at the same relative region as those found using the two other methods (single probe, Morley et al. [2]), even though the PC results are not composed of a single probe. The column "PC" lists the principal component that was used to find the maximum LOD score. The four bottom probes met our p-value < 10-9 criteria but did not appear on Morley's top 13 list. There were an additional 9 probes on Morley's list that were not in our top 45.