Comparison of strategies for identification of regulatory quantitative trait loci of transcript expression traits

BMC Proceedings

Table 2 Univariate transcript heritability and linkage analysis compared to principal-component approach: chromosome 13q34 region

Transcript	Gene Name	Gene Symbol	H² (SE)^a	H² p-value	LOD score	Trait locus location	Transcript gene locus
200805_at	lectin, mannose-binding 2	LMAN2	0.25(0.10)	0.0003	1.3	13q33.2-q34	5q35.3
209375_at	xeroderma pigmentosum, complementation group C	XPC	0.23 (0.13)	0.007	1.8	13q33.2-q34	3p25
211564_s_at	PDZ and LIM domain 4	PDLIM4	0.20 (0.13)	0.01	2.0	13q34	5q31.1
203366_at	polymerase (DNA directed), gamma	POLG	0.21 (0.11)	0.002	2.0	13q34	15q25
210502_s_at	peptidylprolyl isomerase E (cyclophilin E)	PPIE	0.40 (0.13)	<0.001	1.8	13q34	1p32
217922_at	Mannosidase, alpha, class 1A, member 2	MAN1A2	0.21 (0.10)	0.003	1.6	13q34	1p13
209715_at	chromobox homolog 5 (HP1 alpha homolog, Drosophila)	CBX5	0.28 (0.11)	<0.001	2.4	13q34	12q13.13
203880_at	COX17 homolog, cytochrome c oxidase assembly protein (yeast)	COX17	0.28 (0.11)	0.0004	1.3	13q34	3q13.33
201145_at	HCLS1 associated protein X-1	HAX1	0.33 (0.14)	0.0004	2.0	13q34	1q21.3
201157_s_at	N-myristoyltransferase 1	NMT1	0.31 (0.11)	0.0002	2.0	13q34	17q21.31
209219_at	RD RNA binding protein	RDBP	0.36 (0.11)	<0.001	1.6	13q34	6p21.3
217932_at	mitochondrial ribosomal protein S7	MRPS7	0.11 (0.08)	0.05	1.0	13q34	17q25
Principal component analysis, factor 2 (loading HAX1)^b		N/A	0.28 (0.13)	0.001	1.6	13q34	N/A
factor 3 (loading MRPS7)		N/A	0.21 (0.10)	0.003	1.1	13q33.1-33.2	N/A
factor 5 (loading NMT1)		N/A	0.20 (0.12)	0.02	1.9	13q34	N/A

^aH², heritability; se, standard error; N/A, not apply.
^b For principal component analysis, only factors with significant heritability (alpha = 0.05) are shown.

ISSN: 1753-6561