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Table 2 Univariate transcript heritability and linkage analysis compared to principal-component approach: chromosome 13q34 region

From: Comparison of strategies for identification of regulatory quantitative trait loci of transcript expression traits

Transcript Gene Name Gene Symbol H2 (SE)a H2 p-value LOD score Trait locus location Transcript gene locus
200805_at lectin, mannose-binding 2 LMAN2 0.25(0.10) 0.0003 1.3 13q33.2-q34 5q35.3
209375_at xeroderma pigmentosum, complementation group C XPC 0.23 (0.13) 0.007 1.8 13q33.2-q34 3p25
211564_s_at PDZ and LIM domain 4 PDLIM4 0.20 (0.13) 0.01 2.0 13q34 5q31.1
203366_at polymerase (DNA directed), gamma POLG 0.21 (0.11) 0.002 2.0 13q34 15q25
210502_s_at peptidylprolyl isomerase E (cyclophilin E) PPIE 0.40 (0.13) <0.001 1.8 13q34 1p32
217922_at Mannosidase, alpha, class 1A, member 2 MAN1A2 0.21 (0.10) 0.003 1.6 13q34 1p13
209715_at chromobox homolog 5 (HP1 alpha homolog, Drosophila) CBX5 0.28 (0.11) <0.001 2.4 13q34 12q13.13
203880_at COX17 homolog, cytochrome c oxidase assembly protein (yeast) COX17 0.28 (0.11) 0.0004 1.3 13q34 3q13.33
201145_at HCLS1 associated protein X-1 HAX1 0.33 (0.14) 0.0004 2.0 13q34 1q21.3
201157_s_at N-myristoyltransferase 1 NMT1 0.31 (0.11) 0.0002 2.0 13q34 17q21.31
209219_at RD RNA binding protein RDBP 0.36 (0.11) <0.001 1.6 13q34 6p21.3
217932_at mitochondrial ribosomal protein S7 MRPS7 0.11 (0.08) 0.05 1.0 13q34 17q25
Principal component analysis, factor 2 (loading HAX1)b N/A 0.28 (0.13) 0.001 1.6 13q34 N/A
   factor 3 (loading MRPS7) N/A 0.21 (0.10) 0.003 1.1 13q33.1-33.2 N/A
   factor 5 (loading NMT1) N/A 0.20 (0.12) 0.02 1.9 13q34 N/A
  1. aH2, heritability; se, standard error; N/A, not apply.
  2. b For principal component analysis, only factors with significant heritability (alpha = 0.05) are shown.