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Table 3 Marked changes in linkage when age was included as a covariate

From: Sex, age and generation effects on genome-wide linkage analysis of gene expression in transformed lymphoblasts

SNPa

Trait

LOD scores

Rs no.

Location Chr:Mb

Gene

Location Chr:Mb

Without age

With age

Change when age included

rs1505695

02:06.9

ITGB1BP1

02:09.5

3.36

9.82

6.47

rs756019

15:21.2

CREM

10:35.5

0.98

6.14

5.16

rs1749715

15:30.3

SCD

11:42.1

0.92

6.07

5.15

rs1957538

15:21.2

CREM

10:35.5

0.05

5.02

4.97

rs753151

08:48.7

LIF

22:29.0

0.77

5.53

4.76

rs1499511

11:36.0

RASA1

06:26.7

0.55

5.29

4.74

rs1264898

02:51.8

SNX5

20:17.9

0.20

4.82

4.62

rs1503230

03:08.0

LRAP

06:36.3

0.22

4.67

4.45

rs1417594

15:34.4

VPS16

20:02.8

0.33

4.75

4.42

rs1858799

16:23.0

ZNF277

08:51.7

0.75

5.16

4.41

rs1005989

03:08.9

DGUOK

03:14.0

6.40

1.04

-5.36

rs1986778

12:26.9

TNFAIP8

06:58.7

6.02

0.74

-5.28

rs1862802

16:57.0

TLR1

04:38.5

5.51

0.26

-5.26

rs1333798

14:27.5

RECQL4

10:25.7

6.10

1.06

-5.03

rs954779

09:36.4

CDC25C

07:17.7

5.23

0.22

-5.00

rs1341446

04:59.6

PIK3C3

18:37.9

7.61

2.71

-4.89

rs1935886

03:29.8

CHI3L2

02:51.6

11.64

6.78

-4.86

rs1432285

04:14.0

HNRPR

01:23.5

5.56

0.74

-4.82

rs1459359

15:27.7

C3orf4

04:39.7

5.10

0.28

-4.82

rs744531

03:51.7

SLC25A32

09:44.5

5.78

1.00

-4.78

  1. aThe 10 top SNPs and traits for which there is evidence for linkage when age is either included or excluded as a covariate are shown as examples.