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Table 3 Marked changes in linkage when age was included as a covariate

From: Sex, age and generation effects on genome-wide linkage analysis of gene expression in transformed lymphoblasts

SNPa Trait LOD scores
Rs no. Location Chr:Mb Gene Location Chr:Mb Without age With age Change when age included
rs1505695 02:06.9 ITGB1BP1 02:09.5 3.36 9.82 6.47
rs756019 15:21.2 CREM 10:35.5 0.98 6.14 5.16
rs1749715 15:30.3 SCD 11:42.1 0.92 6.07 5.15
rs1957538 15:21.2 CREM 10:35.5 0.05 5.02 4.97
rs753151 08:48.7 LIF 22:29.0 0.77 5.53 4.76
rs1499511 11:36.0 RASA1 06:26.7 0.55 5.29 4.74
rs1264898 02:51.8 SNX5 20:17.9 0.20 4.82 4.62
rs1503230 03:08.0 LRAP 06:36.3 0.22 4.67 4.45
rs1417594 15:34.4 VPS16 20:02.8 0.33 4.75 4.42
rs1858799 16:23.0 ZNF277 08:51.7 0.75 5.16 4.41
rs1005989 03:08.9 DGUOK 03:14.0 6.40 1.04 -5.36
rs1986778 12:26.9 TNFAIP8 06:58.7 6.02 0.74 -5.28
rs1862802 16:57.0 TLR1 04:38.5 5.51 0.26 -5.26
rs1333798 14:27.5 RECQL4 10:25.7 6.10 1.06 -5.03
rs954779 09:36.4 CDC25C 07:17.7 5.23 0.22 -5.00
rs1341446 04:59.6 PIK3C3 18:37.9 7.61 2.71 -4.89
rs1935886 03:29.8 CHI3L2 02:51.6 11.64 6.78 -4.86
rs1432285 04:14.0 HNRPR 01:23.5 5.56 0.74 -4.82
rs1459359 15:27.7 C3orf4 04:39.7 5.10 0.28 -4.82
rs744531 03:51.7 SLC25A32 09:44.5 5.78 1.00 -4.78
  1. aThe 10 top SNPs and traits for which there is evidence for linkage when age is either included or excluded as a covariate are shown as examples.