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Table 1 Chromosome regions showing only additive trans-acting effectsa with 22q11 on COMT expression level

From: Linkage studies of catechol-O-methyltransferase (COMT) and dopamine-beta-hydroxylase (DBH) cDNA expression levels

Genomic region

Closest marker

Physical distance (Mb)

p-Value for λ

3q26

rs1499812

173.2

4.4 × 10-3

4q35

rs1979255

190.7

3.4 × 10-4

5q34

rs1387395

163.8

4.1 × 10-3

6p22

rs1475149

21.8

2.5 × 10-3

7p21

rs988418

9.9

3.7 × 10-3

8q22

rs1075394

101.5

1.8 × 10-3

9q34

rs936249

138.2

2.2 × 10-3

10p11

rs1857063

29.4

2.0 × 10-7

18p11

rs321663

8.6

2.1 × 10-4

20q13

rs756529

47.4

3.1 × 10-3

  1. aAt a nominal level of 0.005