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Table 3 Chromosome regions showing both additive and interactive trans-acting effectsa with 22q11 on COMT expression level

From: Linkage studies of catechol-O-methyltransferase (COMT) and dopamine-beta-hydroxylase (DBH) cDNA expression levels

   

p-Value

Genomic region

Closest marker

Physical distance (Mb)

λ

γ

1q41

rs1561189

213.5

1.1 × 10-4

4.6 × 10-3

2q35

rs1425118

216.8

<1.0 × 10-8

3.5 × 10-2

3q28

rs1559018

191.8

2.3 × 10-2

2.9 × 10-5

4q31

rs795995

141.1

1.5 × 10-3

5.0 × 10-7

5q14

rs1020720

80.5

1.7 × 10-2

1.8 × 10-3

6q16

rs2021678

102.1

1.1 × 10-3

4.7 × 10-2

7p14

rs2051936

40.8

5.7 × 10-3

3.5 × 10-3

8p23

rs433960

12.9

4.7 × 10-2

2.9 × 10-5

9p23

rs1412307

13.0

1.3 × 10-4

6.6 × 10-3

14q13

rs1983667

36.2

1.4 × 10-4

1.1 × 10-2

16p13

rs1981492

0.3

1.0 × 10-3

5.9 × 10-3

16q24

rs880275

84.8

4.7 × 10-3

2.6 × 10-3

17p12

rs433068

15.2

4.8 × 10-2

4.4 × 10-3

22q13

rs960362

47.4

4.8 × 10-4

8.6 × 10-3

  1. aBoth effects attained a nominal significance level of 0.05 and at least one reached the level 0.005.
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BMC Proceedings

ISSN: 1753-6561

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