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Table 3 Chromosome regions showing both additive and interactive trans-acting effectsa with 22q11 on COMT expression level

From: Linkage studies of catechol-O-methyltransferase (COMT) and dopamine-beta-hydroxylase (DBH) cDNA expression levels

    p-Value
Genomic region Closest marker Physical distance (Mb) λ γ
1q41 rs1561189 213.5 1.1 × 10-4 4.6 × 10-3
2q35 rs1425118 216.8 <1.0 × 10-8 3.5 × 10-2
3q28 rs1559018 191.8 2.3 × 10-2 2.9 × 10-5
4q31 rs795995 141.1 1.5 × 10-3 5.0 × 10-7
5q14 rs1020720 80.5 1.7 × 10-2 1.8 × 10-3
6q16 rs2021678 102.1 1.1 × 10-3 4.7 × 10-2
7p14 rs2051936 40.8 5.7 × 10-3 3.5 × 10-3
8p23 rs433960 12.9 4.7 × 10-2 2.9 × 10-5
9p23 rs1412307 13.0 1.3 × 10-4 6.6 × 10-3
14q13 rs1983667 36.2 1.4 × 10-4 1.1 × 10-2
16p13 rs1981492 0.3 1.0 × 10-3 5.9 × 10-3
16q24 rs880275 84.8 4.7 × 10-3 2.6 × 10-3
17p12 rs433068 15.2 4.8 × 10-2 4.4 × 10-3
22q13 rs960362 47.4 4.8 × 10-4 8.6 × 10-3
  1. aBoth effects attained a nominal significance level of 0.05 and at least one reached the level 0.005.