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Figure 1 | BMC Proceedings

Figure 1

From: Investigation of reproducibility of differentially expressed genes in DNA microarrays through statistical simulation

Figure 1

The relationship of POGs with the degree of noise level in the simulated datasets: (A) Low noise (CV = 2%); (B) Medium noise (CV = 10%); (C) High noise (CV = 30%); and (D) Very high noise (CV = 100%). The simulated datasets were set to the expression magnitude difference between the treated and control groups of 1.5 and the sample size of 50. The x-axis represents the number of genes selected as differentially expressed, and the y-axis represents the POG (%) of two gene lists for a given number of differentially expressed genes. Each line on the graph represents the overlap of differentially expressed gene lists based on one of six different gene ranking/selection methods. The red and blue numbers give the POG (%) for 500 selected DEGs (red dashed line) from P rank ordering only and FC rank ordering with P < 0.05, respectively.

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