Figure 2

The relationship of POG with the degree of difference in expression magnitude between the treated versus control groups. (A) Magnitude = 0.6; (B) Magnitude = 1.5; and (C) Magnitude = 0.2. The simulated datasets had CV = 30% and sample size = 50. The x-axis represents the number of genes selected as differentially expressed, and the y-axis represents the POG (%) of two gene lists for a given number of differentially expressed genes. Each line on the graph represents the overlap of differentially expressed gene lists based on one of six different gene ranking/selection methods. The red and blue numbers give the POG (%) when 500 genes (red dashed line) are selected as DEGs using P rank ordering only and FC rank ordering with P < 0.05, respectively.