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Table 1 Revised nomenclature for N-terminal acetyltransferases

From: A synopsis of eukaryotic Nα-terminal acetyltransferases: nomenclature, subunits and substrates

Type

NatA

NatB

NatC

NatD

NatE

Original

     

   Catalytic subunit

Ard1p

Nat3p

Mak3p

Nat4p

Nat5p

   Auxiliary subunit

Nat1p

Mdm20p

Mak10p

 

   

Mak31p

  

Revised

     

   Catalytic subunit

Naa10p

Naa20p

Naa30p

Naa40p

Naa50p

   Auxiliary subunit

Naa15p

Naa25p

Naa35p

 

   

Naa38p

  

Number of yeast substrates

~2,000

~1,000

~250

2?

?

Substrates*

Ser-

Met-Glu-

Met-Ile-

Ser-Gly-etc-

?

 

Ala-

Met-Asp-

Met-Leu-

  
 

Gly-

Met-Asn-

Met-Trp-

  
 

Thr-

 

Met-Phe-

  
 

Val-‡

    
 

Cys-¶

    
 

------------2 to 8 amino acids-----------

30–50 a. a

?

  1. Naa50p is inferred to be an N-terminal acetyltransferase because of its sequence homology to known NATs.
  2. * Acetylation occurs at least partially on all proteins with Met-Glu-, Met-Asp- and Met-Asn- termini, but only on subclasses of proteins with the other termini.
  3. † Naa15p may be an auxiliary subunit of NatE, as well as an auxiliary subunit of NatA.
  4. ‡ Found in humans but not yeast (see Figure 2 legend).
  5. ¶One example found in yeast (see Figure 2 legend).