Table 1 SNPs associated with LDL-C, HDL-C, and TG in GWAS, with the gene that they are in or near
p-Value | ||||||
|---|---|---|---|---|---|---|
Gene | SNP | Chr | Subset 1 | Subset 2 | Overall | Effect size (mg/dL)a |
LDL-C | ||||||
PSRC1b | rs599839 | 1p13 | 9.5 × 10-13 | 1.6 × 10-6 | 2.2 × 10-16 | -16.7 |
CELSR2b | rs4970834 | 1p13 | 5.6 × 10-7 | 6.8 × 10-5 | 1.1 × 10-9 | -10.3 |
PSMA5 | rs17586966 | 1p13 | 1.8 × 10-5 | 3.6 × 10-4 | 2.8 × 10-7 | -8.8 |
MTPN | rs1365360 | 7q33 | 4.2 × 10-4 | 7.8 × 10-4 | 1.4 × 10-6 | 7.7 |
DCDC1/5 | rs158584 | 11p14 | 2.7 × 10-4 | 5.3 × 10-4 | 2.3 × 10-7 | 7.1 |
RORA | rs782918 | 15q22 | 3.2 × 10-4 | 6.3 × 10-4 | 3.1 × 10-7 | -9.8 |
HDL-C | ||||||
LPLc | rs17482753 | 8p21 | 5.4 × 10-10 | 9.2 × 10-6 | 5.5 × 10-13 | 11.1 |
LPL | rs10503669 | 8p21 | 1.1 × 10-9 | 4.9 × 10-6 | 2.5 × 10-13 | 12.4 |
LPL | rs17410962 | 8p21 | 7.4 × 10-8 | 2.9 × 10-5 | 6.9 × 10-11 | 8.5 |
LPL | rs17489268 | 8p21 | 1.1 × 10-9 | 3.5 × 10-6 | 6.6 × 10-15 | 4.5 |
LPL | rs17411024 | 8p21 | 4.6 × 10-8 | 1.5 × 10-5 | 1.6 × 10-11 | 5.5 |
LPL | rs17411031 | 8p21 | 2.1 × 10-9 | 3.2 × 10-6 | 1.3 × 10-14 | 4.5 |
LPL | rs17411126 | 8p21 | 3.3 × 10-9 | 7.7 × 10-6 | 6.1 × 10-14 | 4.4 |
LPL | rs765547 | 8p21 | 4.3 × 10-9 | 6.1 × 10-6 | 4.6 × 10-14 | 4.5 |
LPL | rs11986942 | 8p21 | 1.1 × 10-6 | 4.0 × 10-4 | 3.1 × 10-9 | 3.6 |
LPL | rs1837842 | 8p21 | 4.9 × 10-9 | 1.8 × 10-6 | 1.7 × 10-14 | 4.6 |
LPL | rs1919484 | 8p21 | 5.9 × 10-9 | 2.7 × 10-6 | 3.2 × 10-14 | 4.6 |
CETPc | rs9989419 | 16q13 | 1.1 × 10-4 | 4.6 × 10-4 | 8.2 × 10-7 | -3.6 |
LIPGb | rs7240405 | 18q21 | 1.0 × 10-4 | 6.9 × 10-4 | 5.3 × 10-7 | -3.6 |
LIPG | rs4939883 | 18q21 | 2.9 × 10-5 | 6.2 × 10-4 | 1.7 × 10-7 | -3.6 |
ACAA2b | rs6507945 | 18q21 | 4.6 × 10-4 | 1.0 × 10-4 | 6.8 × 10-7 | -3 |
Triglycerides | ||||||
SUMF1 | rs317608 | 3p26 | 5.7 × 10-4 | 1.4 × 10-4 | 4.0 × 10-7 | 26 |
RASGEF1B | rs4382026 | 4q21 | 6.3 × 10-4 | 3.6 × 10-5 | 5.3 × 10-9 | 22 |
BAZ1B | rs2074755 | 7q11 | 1.4 × 10-5 | 2.0 × 10-4 | 3.9 × 10-10 | -13 |
LPLc | rs17489268 | 8p21 | 1.5 × 10-6 | 1.6 × 10-4 | 9.8 × 10-12 | -13 |
LPL | rs17411031 | 8p21 | 9.3 × 10-7 | 1.6 × 10-4 | 6.0 × 10-12 | -13 |
LPL | rs17411126 | 8p21 | 1.4 × 10-6 | 2.0 × 10-4 | 1.3 × 10-11 | -13 |
LPL | rs765547 | 8p21 | 3.6 × 10-6 | 4.9 × 10-4 | 6.9 × 10-11 | -13 |
LPL | rs1837842 | 8p21 | 4.8 × 10-6 | 3.4 × 10-4 | 7.1 × 10-11 | -13 |
LPL | rs1919484 | 8p21 | 1.7 × 10-5 | 3.3 × 10-4 | 3.6 × 10-10 | -12 |