Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study

BMC Proceedings

Table 4 Unweighted GRS (sum of risk alleles carried, as defined in literature reports [6]) and its association with lipid/lipoprotein levels^a

	Number of risk alleles carried				Mean (LDL-C & HDL-C)/median (TG) in GRS by quartile
GRS	Min	Max	Mean	S.D.	1	2	3	4	p-Value
	6	20	12.8	2.1
LDL-C					112.8	113.4	117.9	119.9	3.6 × 10^-7
HDL-C					56.2	53.8	51.8	51.2	6.4 × 10^-16
TG					75.0	84.0	84.0	87.0	4.1 × 10^-10

^aResults of association testing using a linear mixed model with family membership included in the model as a random-effects variable. Phenotype values are in mg/dL

ISSN: 1753-6561