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Table 5 Weighted GRS composed from both SNP and haplotype markersa

From: Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study

     

Mean (LDL-C & HDL-C)/median (TG) in GRS by quartiles

 

GRS

Min

Max

Mean

S.D.

1

2

3

4

p-Value

GRS-LDL

-34.8

21

-1.59

7.3

     

   LDL-C

    

107.7

115.2

119.1

122.7

6.0 × 10-28

   HDL-C

    

54.3

53.5

53.2

53.2

0.22

   TG

    

79.0

81.0

83.0

79.0

0.055

GRS-HDL

-27.0

17

-1.74

3.6

     

   LDL-C

    

115.7

116.4

117.2

115.5

0.53

   HDL-C

    

50.5

51.7

54.9

56.9

6.2 × 10-25

   TG

    

84.0

84.5

83.0

75.0

5.6 × 10-8

GRS-TG

-32.0

31

-2.59

8.4

     

   LDL-C

    

114.5

118.2

116.8

116.2

0.07

   HDL-C

    

55.0

53.5

52.5

52.6

4.5 × 10-5

   TG

    

72.0

81.0

85.0

90.0

6.7 × 10-23

  1. aResults of association testing using a linear mixed model with family membership included in the model as a random-effects variable. Phenotype values are in mg/dL