Tests for candidate-gene interaction for longitudinal quantitative traits measured in a large cohort

BMC Proceedings

Table 1 Gene-gene interaction for BMI in FHS data^a

	LNPT analysis of independent individuals in Offspring Cohort^b (n= 824) for the trait Longitudinal BMI		Survival analysis of independent individuals in Original and Offspring Cohorts (n= 858) for the trait Event Overweight (BMI ≥ 25)
Modelled factors	Sex and two gene factors		Sex, cohort, and two gene factors
Age adjustment	No	Yes	Age is event time
Time-varying covariates	No^b	No^b	No	Yes^h
SNP pair
rs854560 and rs6602024^c-e
analyzing exams (T = 1, 4)^d	0.022 ^g	0.040 ^g	0.003	0.007
analyzing exams (T = 1,3,4)^d	0.092^g	n.s.	0.003	0.007
rs854560 and rs1121980	0.034 ^f	0.003 ^f	0.030	0.053
rs854560 and rs9930506	0.048 ^f	0.004 ^f	0.005	0.008
rs6971091^c and rs6602024^{c, e}	n.s.	n.s.	n.s.	n.s.
rs6971091^c and rs1121980	n.s.	n.s.	n.s.	n.s.
rs6971091^c and rs9930506	n.s.	n.s.	n.s.	n.s.
rs6602024^{c, e}and rs1121980	0.053^g	0.049 ^g	0.020	0.028
rs6602024^{c, e}and rs9930506	n.s.	n.s.	0.077	n.s.

^ap-Values ≤ 0.1 are given, otherwise marked as not significant (n.s.). Bold font indicates p-values ≤ 0.05.
^bIndividuals with no cholesterol treatment and baseline age 25-46 yr, Exams T = 1,3,4.
^cCarriers of the rare allele for the SNP were pooled for LNPT analysis.
^dSNP pair has a small two-locus genotype strata. LNPT analysis was performed for two sets of exams. Survival analysis used all available event times.
^eMinor allele homozygotes for this SNP were omitted for survival analysis.
^fInteraction of SNP1-SNP2 with number of exam (averaged for sex).
^gInteraction of SNP1-SNP2 with sex and exam number.
^hInclusion of time-varying covariates smoking status and cholesterol treatment.

ISSN: 1753-6561