Figure 1
From: MetaPath: identifying differentially abundant metabolic pathways in metagenomic datasets
Schematic diagram of the MetaPath methods.Sequences from each sample are annotated against KEGG genes database andmapped to reactions in metabolic networks, resulting an abundance matrix where therows are reactions and columns are samples. Then p values are computed for allreactions using Metastats [9], then converted into Z values, and greedy search isperformed on the edge-weighted graph to find max-weight subnetworks. Finally, wecalculate the pabund and pstruct significance values of the max-weight subnetwork.