Polymorphisms in pattern recognition receptors and their relationship to infectious disease susceptibility in pigs

Table 1 Distribution of polymorphisms in CDSs of porcine PRRs

Gene	All			Region for ligand recognition			Region for signal transduction
	All	NonSyn	Syn	All	NonSyn	Syn	All	NonSyn	Syn
TLR1	45	21	24	34	17	17	5	1	4
TLR2	23	11	12	17	10	7	3	1	2
TLR3	15	6	9	9	3	6	2	0	2
TLR4	13	7	6	10	7	3	1	0	1
TLR5	35	13	22	21	11	10	12	1	11
TLR6	20	11	9	14	10	4	2	0	2
TLR7	15	3	12	12	3	9	2	0	2
TLR8	22	9	13	20	7	13	0	0	0
NOD2	44*	14*	30	17	7	10	6	1	5
DDX58 (RIG-I)	17	6	11	8	2	6	3	1	2
IFIH1 (MDA5)	3	3	0	1	1	0	0	0	0

SNPs derived from 11 breeds, including Japanese wild boar (except for NOD2, DDX58, and IFIH1; six breeds of pig were used) were examined for polymorphisms. SNPs observed in the entire CDSs (All), in the ligand recognition region, and in the signal transduction region are indicated. Numbers of polymorphisms of NOD2include an insertion/deletion polymorphism located in the signal leader sequence (indicated by asterisks). NonSyn, nonsynonymous SNPs; Syn, synonymous SNPs.

ISSN: 1753-6561